S-1-boc-4-cbz-2-甲基哌嗪合成路线 (共 2 条)
反应条件
hydrogen; palladium 10 on activated carbon in methanol
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2005/66139 A2, 2005 ;
Location in patent: Page/Page column 134 ;
WO 2005/066139 A2
反应条件
1: (S)-(+)-2-Methylpiperazine; benzyl chloroformate in dichloromethane
T=0 - 20°C; 3 h;
2: di-tert-butyl dicarbonate With N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2005/66139 A2, 2005 ;
Location in patent: Page/Page column 134 ;
WO 2005/066139 A2