3-氟-4-(甲基亚磺酰基)苯酚合成路线 （共 4 条）
反应条件
Oxonereg; in tetrahydrofuran; water
T=20°C; 1 h;
参考文献
Erickson, Shawn David; Gillespie, Paul; Guertin, Kevin Richard; Karnachi, Prabha Saba; Kim, Kyungjin; Ma, Chun; McComas, Warren William; Pietranico-Cole, Sherrie Lynn; Qi, Lida; Tilley, Jefferson Wright; Zhang, Qiang
Patent: US2009/286812 A1, 2009 ;
Location in patent: Page/Page column 19 ;
反应条件
1.1: iron; acetic acid / water / |Inert atmosphere
2.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / |Inert atmosphere
2.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C
3.1: Oxonereg; / tetrahydrofuran; water / 3 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
HYUNDAI PHARM CO., LTD.; YANG, Jin; KIM, Jinwoong; LEE, Hankyu; KIM, Jaehyun; SON, Changmo; LEE, Kyuhwan; CHOI, Hyungho; KIM, Daehoon; CHOI, Hyosun; RHEE, Jaekeol
Patent: WO2013/105753 A1, 2013 ;
反应条件
1.1: tetrahydrofuran; N,N-dimethyl-formamide / 4 h / 20 °C / |Inert atmosphere
2.1: iron; acetic acid / water / |Inert atmosphere
3.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / |Inert atmosphere
3.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C
4.1: Oxonereg; / tetrahydrofuran; water / 3 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
HYUNDAI PHARM CO., LTD.; YANG, Jin; KIM, Jinwoong; LEE, Hankyu; KIM, Jaehyun; SON, Changmo; LEE, Kyuhwan; CHOI, Hyungho; KIM, Daehoon; CHOI, Hyosun; RHEE, Jaekeol
Patent: WO2013/105753 A1, 2013 ;
反应条件
1.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / |Inert atmosphere
1.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C
2.1: Oxonereg; / tetrahydrofuran; water / 3 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
HYUNDAI PHARM CO., LTD.; YANG, Jin; KIM, Jinwoong; LEE, Hankyu; KIM, Jaehyun; SON, Changmo; LEE, Kyuhwan; CHOI, Hyungho; KIM, Daehoon; CHOI, Hyosun; RHEE, Jaekeol
Patent: WO2013/105753 A1, 2013 ;
