2,3-二甲氧基苯甲醛合成路线 （共 174 条）
反应条件
1: toluene / Heating
2: 87 percent / BBr3 / CH2Cl2 / 3 h / Heating
View Scheme
参考文献
Dubuffet; Loutz; Lavielle
Synthetic Communications, 1999 , vol. 29, # 6 p. 929 - 936
反应条件
1: AcOH, NaCNBH3 / ethanol / Heating
2: 2 M Na2CO3 / toluene / Ambient temperature
3: aq. 6 N HCl / dioxane / 0.33 h / Heating
4: 75 percent / W-2 Raney nickel / dioxane / 3 h / Heating
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参考文献
Hirano; Osawa; Yamaoka; Yokoi
Biological and Pharmaceutical Bulletin, 2001 , vol. 24, # 11 p. 1277 - 1281
反应条件
1: silver tetrafluoroborate; [{(η5-C5Me5)RhCl}2(μ-Cl)2]; copper diacetate / 1,1-dimethylpropan-1-ol / 3 h / 110 °C / Inert atmosphere
2: K3Fe(CN)6; CsOH / methanol; water / 12 h / 80 °C / Inert atmosphere
3: pyridinium chlorochromate / dichloromethane / Inert atmosphere
4: hydrogenchloride; acetic acid / water / Inert atmosphere
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参考文献
Jayakumar, Jayachandran; Parthasarathy, Kanniyappan; Cheng, Chien-Hong
Angewandte Chemie - International Edition, 2012 , vol. 51, # 1 p. 197 - 200
反应条件
2: H2, aq. H2SO4 / Pd-C / ethyl acetate
3: Py*HCl / Heating
View Scheme
参考文献
Kurtz,A.P.; Dawson,C.R.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 729 - 732
参考文献
Farina; Pinza; Gamba; Pifferi
European Journal of Medicinal Chemistry, 1979 , vol. 14, # 1 p. 27 - 31
反应条件
(i) NH2OH, (ii) H2, Pd-C, HCl, EtOH, (iii) aq. HCl; Multistep reaction;
参考文献
Epstein,J. et al.
Journal of the American Chemical Society, 1964 , vol. 86, p. 4959 - 4963
反应条件
1: potassium cyanide; aqueous ethanol
2: ethanol; coppered tin; concentrated aqueous hydrochloric acid
3: sodium acetate; ethanol; hydroxylamine hydrochloride
4: sodium-amalgam; ethanol; acetic acid
View Scheme
参考文献
Hartwell; Kornberg
Journal of the American Chemical Society, 1945 , vol. 67, p. 1606
参考文献
Sah; Peoples
Journal of the American Pharmaceutical Association (1912-1977), 1954 , vol. 43, p. 513,514
反应条件
1: AgNO3; NaOH
2: SOCl2
View Scheme
参考文献
Stuart; Khora; McKenney Jr.; Castle
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1589 - 1594
反应条件
2-HEAF
T=20°C; Knoevenagel condensation; 1.5 h; Ionic liquid;
参考文献
Alizadeh, Abdolhamid; Khodaei, Mohammad M.; Eshghi, Ali
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8295 - 8298
