2,3-二甲氧基苯甲醛合成路线 （共 174 条）
反应条件
1: AcOH / ethanol / 18 h / Heating
2: NaBH4 / methanol / 1 h / Ambient temperature
3: 91 percent / acetic anhydride / 1 h / 70 °C
4: 92 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature
5: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 1 h
6: 80 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
7: 98 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: permanganate
2: hydrogen iodide / 100 °C
3: aqueous-alcoholic KOH-solution; hydrogen stream
4: thionyl chloride
5: benzene; ammonia
View Scheme
参考文献
Perkin; Trikojus
Journal of the Chemical Society, 1926 , p. 2932
反应条件
1: triethylamine; zinc(II) chloride / dichloromethane / 96 h / Inert atmosphere; Reflux
2: 6 h / 180 °C / Inert atmosphere
3: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 1520.1 Torr
4: PPA / 0.5 h / 60 °C / Inert atmosphere
5: boron trifluoride diethyl etherate / toluene / 3 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Bonner, Lisa A.; Laban, Uros; Chemel, Benjamin R.; Juncosa, Jose I.; Lill, Markus A.; Watts, Val J.; Nichols, David E.
ChemMedChem, 2011 , vol. 6, # 6 p. 1024 - 1040
反应条件
1: 81 percent
2: 82 percent
3: 68.3 percent
4: 56 percent / H2 / 10percent Pd/C
View Scheme
参考文献
Nachtsheim, Corina M.; Frahm, August W.
Archiv der Pharmazie (Weinheim, Germany), 1989 , vol. 322, p. 187 - 197
反应条件
1: tetrabutylammomium bromide; sodium hydroxide / water / 0.08 h / |Microwave irradiation
2: pyridine / water / 3 h / 20 °C
View Scheme
参考文献
Liu, Gui-Xiang; Wan, Yu; Zhao, Ling-Ling; Wang, Hai-Ying; Xu, Zhou; Qi, Jin-Long; Wu, Hui
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7828 - 7830
反应条件
1.1: potassium hydroxide / ethanol / 12 h / 0 - 20 °C
1.2: pH 3 - 4 / |Cooling with ice
2.1: Aspergillus niger LSPN001 / ethanol / 120 h / 20 °C / |Enzymatic reaction
View Scheme
参考文献
Alarcon, Julio; Alderete, Joel; Escobar, Carlos; Araya, Ramiro; Cespedes, Carlos L.
Biocatalysis and Biotransformation, 2013 , vol. 31, # 4 p. 160 - 167
反应条件
1: 99 percent / NaBH4 / methanol / 1 h / 20 °C
2: 95 percent / SOCl2; pyridine / CHCl3 / 0.75 h / 20 °C
3: 99 percent / ethanol; H2O / 1 h / Heating
View Scheme
参考文献
Itoh; Oka
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 2862 - 2867
反应条件
1: 58 percent / NaOAc; Ac2O / 8 h / 100 °C
2: 23 percent / aq. HCl / 4 h / 100 °C
3: boron tribromide / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Bailly, Fabrice; Maurin, Cedric; Teissier, Elisabeth; Vezin, Herve; Cotelle, Philippe
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5611 - 5618
反应条件
1: diethyl ether
2: ethanol; palladium/charcoal / Hydrogenation
3: HCl; glacial acetic acid / 125 °C
View Scheme
参考文献
Kurtz,A.P.; Dawson,C.R.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 729 - 732
反应条件
1: 49 percent / HNO3 / acetic acid / 0.75 h / Ambient temperature
2: 95 percent / boron tribromide / CH2Cl2 / Ambient temperature
3: 76 percent / sodium acetate / 1.5 h / 70 °C
4: 70 percent / KF, 18-crown-6, N-methylmorpholine / 21 h / 10 °C
5: 96 percent / silica gel, reduced iron powder, glacial AcOH / toluene / 0.5 h / 90 °C
6: 54 percent / Na2S2O4, aq. NaOH / dimethylformamide / 0.33 h / 5 °C
View Scheme
参考文献
Fukuyama, Yoshiyasu; Iwatsuki, Chie; Kodama, Mitsuaki; Ochi, Masamitsu; Kataoka, Kumi; Shibata, Kozo
Tetrahedron, 1998 , vol. 54, # 34 p. 10007 - 10016
