2,3-二甲氧基苯甲醛合成路线 （共 174 条）
反应条件
1: sodium tetrahydroborate / dichloromethane / 0.5 h / 20 °C
2: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C
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参考文献
Feng, Lianshun; Lv, Kai; Liu, Mingliang; Wang, Shuo; Zhao, Jing; You, Xuefu; Li, Sujie; Cao, Jue; Guo, Huiyuan
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 125 - 136
反应条件
1: 1.) HNO3, 2.) KMnO4, 2percent aq. NaOH / 2.) 60 deg C, 1.5 h
2: 100 percent / H2 / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr
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参考文献
Grosso, John A.; Nichols, David E.; Kohli, Jai D.; Glock, Dana
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 703 - 708
反应条件
1: potassium cyanide; aqueous ethanol
2: copper (II)-sulfate; aqueous pyridine
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参考文献
Hartwell; Kornberg
Journal of the American Chemical Society, 1945 , vol. 67, p. 1606
反应条件
potassium cyanide; ethanol
参考文献
Hartwell; Kornberg
Journal of the American Chemical Society, 1945 , vol. 67, p. 1606
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Winternitz; Mousseron
Bulletin de la Societe Chimique de France, 1948 , p. 1087,1090
反应条件
1: H2, FeCl3 / PtO2 / ethanol
2: SOCl2
3: H2O
4: LiAlH4
5: aq. HCl / 160 °C
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参考文献
Epstein,J. et al.
Journal of the American Chemical Society, 1964 , vol. 86, p. 4959 - 4963
反应条件
(i), (ii) H2, aq. H2SO4, Pd-C, AcOEt, (iii) Py*HCl; Multistep reaction;
参考文献
Kurtz,A.P.; Dawson,C.R.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 729 - 732
反应条件
1: (i) HBr, benzene, (ii) P(OEt)3, (iii) /BRN= 908264/, NaOMe, DMF
2: H2, FeCl3 / PtO2 / aq. ethanol
3: BBr3 / CH2Cl2
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参考文献
Huneck,S.
Tetrahedron, 1976 , vol. 32, p. 109 - 113
反应条件
1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C
2: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 - 20 °C
3: 120 °C / Inert atmosphere
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参考文献
BAYLOR COLLEGE OF MEDICINE; SONG, Yongcheng
Patent: WO2011/46920 A1, 2011 ;
反应条件
1: (i) HBr, benzene, (ii) P(OEt)3, (iii) /BRN= 908264/, NaOMe, DMF
2: H2, FeCl3 / PtO2 / aq. ethanol
View Scheme
参考文献
Huneck,S.
Tetrahedron, 1976 , vol. 32, p. 109 - 113
反应条件
1: (i) KOtBu, tBuOH, (ii) H2, Pd-C, EtOH, (iii) PCl5, SnCl4, benzene
2: AlCl3 / benzene
3: (i) K2CO3, KI, Na2S2O3, EtOH, (ii) KOH
4: NaBH4 / methanol
5: KHSO4 / benzene
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参考文献
Itoh; Sugihara; Miyake; Tada; Oka
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 2 p. 504 - 513
