2,3-二甲氧基苯甲醛合成路线 （共 174 条）
反应条件
1: CH2Cl2 / 24 h / 20 °C 2: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3: 81 percent / Et3N / CH2Cl2 / 1.5 h / 0 °C 4: 91 percent / m-CPBA / CH2Cl2 / 1 h / 0 °C 5: 25 percent / CH3SO3H / CCl4 / 0.33 h / Heating 6: 90 percent / Raney Ni / ethanol / 2 h / Heating 7: POCl3; K2CO3 / acetonitrile / 0.67 h / 60 °C 8: NaBH4 / methanol / 1 h / Heating View Scheme
参考文献
Hanaoka, Miyoji; Hirasawa, Taeko; Cho, Won Jea; Yasuda, Shingo
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 3 p. 399 - 404
参考文献
Bessin,P. et al.
Chimica Therapeutica, 1969 , vol. 4, p. 220 - 223
反应条件
acetic acid in ethanol
参考文献
Am. Home Prod. Corp.
Patent: DE1802394 , 1969 ;
Chem.Abstr., 1969 , vol. 71, # 60991
反应条件
2-HEAF T=20°C; Knoevenagel condensation; 1.3 h; Ionic liquid;
参考文献
Alizadeh, Abdolhamid; Khodaei, Mohammad M.; Eshghi, Ali
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8295 - 8298
反应条件
1: (i), (ii) H2, aq. H2SO4, Pd-C, AcOEt 2: Py*HCl / Heating View Scheme
参考文献
Kurtz,A.P.; Dawson,C.R.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 729 - 732
反应条件
1: alcoholic KOH-solution 2: diluted hydrobromic acid View Scheme
参考文献
Perkin; Stoyle
Journal of the Chemical Society, 1923 , vol. 123, p. 3174
反应条件
1: 85 percent / BBr3 / CH2Cl2 / 24 h / Ambient temperature 2: 1.) KF / 1.) DMF, 50 deg C, 20 min; 2.) 120 deg C, 3 h View Scheme
参考文献
Perkin; Trikojus
Journal of the Chemical Society, 1926 , p. 2932
反应条件
palladium 10 on activated carbon; hydrogen; acetic acid in ethyl acetate T=20°C; 72 h;
参考文献
Lee, Chia-Lin; Huang, Chi-Huan; Wang, Hui-Chun; Chuang, Da-Wei; Wu, Ming-Jung; Wang, Sheng-Yang; Hwang, Tsong-Long; Wu, Chin-Chung; Chen, Yeh-Long; Chang, Fang-Rong; Wu, Yang-Chang
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 1 p. 70 - 73
反应条件
1: permanganate 2: hydrogen iodide / 100 °C View Scheme
参考文献
Perkin; Trikojus
Journal of the Chemical Society, 1926 , p. 2932
反应条件
1: 62 percent / KMnO4, 10percent aq. NaOH / 1.) 50 deg C, 1 h; 2.) room temp., 12 h. 2: SOCl2 / benzene / Heating; overnight 3: NaN3 / tetrabutylammonium bromide / H2O; CH2Cl2 / 2 h / 0 °C 4: CH2Cl2 / 60 h / Heating 5: 39 percent / K2CO3 / methanol; H2O / 20 h / Ambient temperature View Scheme
参考文献
Stuart; Khora; McKenney Jr.; Castle
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1589 - 1594
