反应条件
1: (COCl)2, DMF / CH2Cl2 / 2 h / Ambient temperature 2: Et3N / CH2Cl2 / Ambient temperature 3: 1.) SOCl2, 2.) aq. K2CO3 / 1.) CH2Cl2, r.t., overnight, 2.) MeCN, reflux, 5 h 4: n-BuLi, HMPA / 1.) THF, hexane, -5 deg C, 45 min; -78 deg C, 1 h, 2.) -78 deg C, 20 min; -78 to -20 deg C, 3 h 5: 95 percent / conc. aq. HCl / 0.33 h 6: 82 percent / aq. NaOH, n-BuNH2 / 12 h / 120 - 125 °C 7: 85 percent / 6 N aq. HCl / 6 h / Heating View Scheme
参考文献
Shimano, Masanao; Meyers, A. I.
Journal of Organic Chemistry, 1995 , vol. 60, # 23 p. 7445 - 7455
