3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
potassium hydroxide in methanol T=20°C; Claisen condensation; 24 h;
参考文献
Singh, Om V.; Muthukrishnan; Sunderavadivelu
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 12 p. 2575 - 2581
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2 h;
参考文献
Brown, Eric; Daugan, Alain
Tetrahedron, 1989 , vol. 45, # 1 p. 141 - 154
反应条件
1: 4-methoxybenzyl-triphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1.5 h; 2: 3,4,5-trimethoxy-benzaldehyde in tetrahydrofuran; hexane T=-78 - 20°C; Wittig reaction; 19 h;
参考文献
Chang, Jang-Yang; Yang, Ming-Fang; Chang, Chi-Yen; Chen, Chi-Ming; Kuo, Ching-Chuan; Liou, Jing-Ping
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6412 - 6415
反应条件
1: 2-methoxy-1,3-butadiene; triphenyl(prop-2-ynyl)phosphonium bromide With zinc(II) iodide; zinc; CoBr2(1,2-bis(diphenylphosphino)ethane) in dichloromethane T=20°C; Diels-Alder reaction; 0.5 h; 2: 3,4,5-trimethoxy-benzaldehyde With potassium tert-butylate in dichloromethane T=20°C; 1 h; 3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in benzene T=20°C; 1 h; Further stages.;
参考文献
Hilt, Gerhard; Hengst, Christoph
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7337 - 7342
反应条件
1: piperidine; pyridine / Heating 2: LAH / tetrahydrofuran / 20 °C View Scheme
参考文献
Cooper,P.D.
Canadian Journal of Chemistry, 1970 , vol. 48, p. 3882 - 3888
反应条件
lithium hexamethyldisilazane in hexane; benzene T=-20°C; 0.0833333 h; Yield given. Yields of byproduct given;
参考文献
Trazzi, Giordano; Andre, Marcelo Fabiano; Coelho, Fernando
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 12 p. 2327 - 2339
反应条件
1: hexamethyldisilylamidure de lithium / benzene; hexane / 0.08 h / -20 °C 2: 77 percent / Jones / acetone / 0.25 h 3: 10 percent / NaBH4 / CH2Cl2; methanol / 0.25 h / 0 - 20 °C View Scheme
参考文献
Robin, Jean-Pierre; Dhal, Robert; Brown, Eric
Tetrahedron, 1982 , vol. 38, # 24 p. 3667 - 3671
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane T=50°C; 96 h;
参考文献
Alvarez; Granados; Lavilla; Salas
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 745 - 750
反应条件
triethylammonium formate T=95 - 100°C; 72 h;
参考文献
Toth; Kover
Synthetic Communications, 1995 , vol. 25, # 19 p. 3067 - 3074
反应条件
1: 89 percent / piperidine / acetic acid / 0.03 h / microwave irradiation 2: 86 percent / PdCl2; formic acid / aq. NaOH; propan-2-ol / 0.05 h / microwave irradiation View Scheme
参考文献
Slotta; Heller
Chemische Berichte, 1930 , vol. 63, p. 3029,3043
