3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
1: (i) KOtBu, (ii) /BRN= 3595639/, Ac2O
2: KOH, aq. EtOH
3: H2SO4
View Scheme
参考文献
Bell,K.H.; Weiss,U.
Australian Journal of Chemistry, 1965 , vol. 18, p. 1273 - 1277
反应条件
1: potassium hydroxide / ethanol / 200 h
2: 0.777 g / H2O2; NaOH / methanol; H2O / 26 h / 0 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
反应条件
palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in acetone
T=50°C; Inert atmosphereGlovebox;
参考文献
Tschaen, Brittany A.; Schmink, Jason R.; Molander, Gary A.
Organic Letters, 2013 , vol. 15, # 3 p. 500 - 503
反应条件
1: 1) piperidine, 2) conc. H2SO4 / 1) pyridine
2: hydrogen / 5percent Pd/C / ethanol
3: sodium wire / diethyl ether / 18 h / Ambient temperature
4: ethanol / 7 h / Heating
5: 90 percent / aq. NaOH / ethanol / 60 °C
6: 38 percent / 5 h / 140 - 150 °C
View Scheme
参考文献
Brown; Blakemore; Durant; Emmett; Ganellin; Parsons; Rawlings; Walker
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 53 - 62
反应条件
1: 30 percent / AlCl3 / CH2Cl2 / 12 h / 20 °C
2: 75 percent / triethylamine / 2 h / 20 °C
View Scheme
参考文献
Zou, Hong Bin; Dong, Sheng Yi; Zhou, Chang Xin; Hu, Li Hong; Wu, Yi Hang; Li, Hai Bo; Gong, Jing Xu; Sun, Lian Li; Wu, Xiu Mei; Bai, Hua; Fan, Bo Tao; Hao, Xiao Jiang; Stoeckigt, Joachim; Zhao, Yu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 2060 - 2071
反应条件
in ethanol; water
T=20°C;
参考文献
Soares, Maria I.L.; Brito, Ana Filipa; Laranjo, Mafalda; Paixao, Jose A.; Botelho, M.Filomena; Pinho E Melo, Teresa M.V.D.
European Journal of Medicinal Chemistry, 2013 , vol. 60, p. 254 - 262
反应条件
N-iodo-succinimide in acetonitrile
参考文献
Broady, Simon D.; Golden, Michael D.; Leonard, John; Muir, James C.; Maudet, Mickael
Tetrahedron Letters, 2007 , vol. 48, # 26 p. 4627 - 4630
反应条件
1: NaBH4
2: N-bromosuccinimide / CCl4
View Scheme
参考文献
Paleo, M. Rita; Lamas, Carlos; Castedo, Luis; Dominguez, Domingo
Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 2029 - 2033
反应条件
1: 96 percent / NBS / acetonitrile
2: 88 percent / toluene
View Scheme
参考文献
Broady, Simon D.; Golden, Michael D.; Leonard, John; Muir, James C.; Maudet, Mickael
Tetrahedron Letters, 2007 , vol. 48, # 26 p. 4627 - 4630
反应条件
1: 90 percent / tributylphosphine / benzene / 2.5 h
2: 1) BuLi /hexane / 1) THF, -78 deg C, 20 min, 2) THF, r. t.
3: 1) Raney nickel, 2) H2, Pd/C / 1) 1,2-dimethoxyethane, ice-cooling, 2) acetic acid/water
View Scheme
参考文献
Tomioka; Ishiguro; Koga
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 10 p. 4333 - 4337
