3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
1: 90 percent / H2 / Pt/C / methanol; H2O
2: 31 percent / 1 h / 168 - 169 °C
View Scheme
参考文献
Elslager, Edward F.; Johnson, Judith L.; Werbel, Leslie M.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 140 - 145
反应条件
sodium ethanolate in ethanol
24 h; Ambient temperature;
参考文献
Bousquet, E.; Guerrera, F.; Siracusa, M. A.; Matera, M.; Bernardini, R.; Conforto, G.
Farmaco. Prat., 1983 , vol. 38, # 10 p. 811 - 816
反应条件
1: 83 percent / NH4Cl / methanol / 3 h / Heating
2: 75 percent / 1) Na, 2) 1N HCl / tetrahydrofuran / 53 h / Ambient temperature
View Scheme
参考文献
EXONHIT S.A.; LEBLOND, Bertrand; TAVERNE, Thierry; BEAUSOLEIL, Eric; CHAUVIGNAC, Cedric; CASAGRANDE, Anne-Sophie; DESIRE, Laurent
Patent: WO2011/151423 A1, 2011 ;
反应条件
ammonium acetate; 2-methylpyridinium trifluoromethanesulphonate in water
T=20°C; 0.1 h; Green chemistry;
参考文献
Tajbakhsh, Mahmood; Alinezhad, Heshmatollah; Norouzi, Mohammad; Baghery, Saeed; Akbari, Maryam
Journal of Molecular Liquids, 2013 , vol. 177, p. 44 - 48
反应条件
in methanol
12 h; Heating;
参考文献
Sainani, J. B.; Shah, A. C.; Arya, V. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, # 6 p. 526 - 531
反应条件
in ethanol
1.5 h; Heating;
参考文献
Vitolinya, R. O.; Stankevich, E. I.; Grinshtein, E. E.; Dreimane, A. Ya.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 1 p. 17 - 19
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 1 p. 39 - 42
反应条件
1: <PhCH2NMe3>OH / tetrahydrofuran; methanol / 12 h / Heating
2: HCl / 1.5 h / Heating
View Scheme
参考文献
Ogura,K. et al.
Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 2013 - 2022
反应条件
1: aq. NaOH
2: NaBH4 / methanol
View Scheme
参考文献
Astoin; Marivain; Riveron; et al.
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 1 p. 41 - 47
反应条件
1: NaBH4
2: N-bromosuccinimide / CCl4
3: 1.) NaH / 1.) DMF, 0 deg C, 2.) rt, 3 h
4: 1.) t-BuLi, 2.) methanol / 1.) THF, pentane, -100 to -95 deg C, 30 min, 2.) rt
5: methanol, trifluoroacetic acid / tetrahydrofuran; pentane / 36 h / Ambient temperature
View Scheme
参考文献
Paleo, M. Rita; Lamas, Carlos; Castedo, Luis; Dominguez, Domingo
Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 2029 - 2033
反应条件
tetrachlorosilane in ethanol
T=20°C; 13 h;
参考文献
Salama, Tarek A.; Ismail, Mohamed A.; Khalil, Abdel-Galil M.; Elmorsy, Saad S.
Arkivoc, 2012 , vol. 2012, # 9 p. 242 - 253
