3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
zinc(II) chloride
1. acetic anhydride, room temperature, 48 h, 2. H2O, benzene, 1 h; Yield given. Multistep reaction;
参考文献
Arnold, Zdenek; Kral, Vladimir; Dvorak, Dalimil
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 11 p. 2602 - 2612
反应条件
1.1: aniline hydrochloride
2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 45 percent / TMEDA / tetrahydrofuran; hexane / 25 °C
3.1: 51 percent / HgO; HgCl2 / acetonitrile; H2O / 16 h / 20 °C
View Scheme
参考文献
Wu, Maojiang; Sun, Qiming; Yang, Chunhao; Chen, Dongdong; Ding, Jian; Chen, Yi; Lin, Liping; Xie, Yuyuan
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 869 - 873
反应条件
in methanol
0.5 h; Heating;
参考文献
Mazzone; Bonina; Puglisi; Panico; Arrigo Reina
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 5 p. 414 - 420
反应条件
acetic acid in water
参考文献
Nanda, Samik; Kato, Yasuo; Asano, Yasuhisa
Tetrahedron, 2005 , vol. 61, # 46 p. 10908 - 10916
反应条件
1: ZnI2
2: aq. HCl / tetrahydrofuran
View Scheme
参考文献
Almsick, Andreas van; Buddrus, Joachim; Hoenicke-Schmidt, Petra; Laumen, Kurt; Schneider, Manfred P.
Journal of the Chemical Society, Chemical Communications, 1989 , # 18 p. 1391 - 1393
反应条件
1: 100 percent / benzene / 5.25 h / Heating
2: 100 percent / hydrogen / platinum(IV) oxide / ethanol / 2.5 h / 760 Torr
3: 94 percent / pyridine / 72 h / Ambient temperature
4: 76 percent / 6 M aq. HCl / dioxane / 24 h / Heating
5: 76 percent / N-bromosuccinimide / tetrahydrofuran / 3 h / Ambient temperature
6: 1.) butyllithium / 1.) hexane, THF, -78 deg C, 15 min, 2.) hexane, THF, 30 min
7: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 30 min, 2.) CH2Cl2, from -60 deg C to RT
View Scheme
参考文献
Banwell, Martin G.; Bonadio, Anna; Turner, Kathleen A.; Ireland, Neil K.; Mackay, Maureen F.
Australian Journal of Chemistry, 1993 , vol. 46, # 3 p. 325 - 351
反应条件
1: trifluoroacetic acid
2: hydrazine hydrate / ethanol / 45 h / 20 °C / |Reflux
View Scheme
参考文献
Moshkin, Vladimir S.; Sosnovskikh, Vyacheslav Ya.
Tetrahedron Letters, 2013 , vol. 54, # 44 p. 5869 - 5872
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
1.2: 4 h / |Acidic conditions
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 9 h / |Reflux
View Scheme
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
sodium hydrogencarbonate in methanol
4 h; Heating;
参考文献
Chan; Laughton; Queener; Stevens
Journal of Medicinal Chemistry, 2001 , vol. 44, # 16 p. 2555 - 2564
反应条件
1: 96 percent / N-bromosuccinimide / CHCl3 / 3 h / Heating
2: 74 percent / Cu / dimethylformamide / 18 h / Heating
View Scheme
参考文献
Brown, Eric; Robin, Jean-Pierre; Dhal, Robert
Tetrahedron, 1982 , vol. 38, # 16 p. 2569 - 2580
