3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
1: 87 percent / Br2; AcOH / CH2Cl2 / 0.5 h / 0 °C
2: 97 percent / 1,1,3,3-tetramethylguanidine / CH2Cl2 / 48 h / 23 °C
3: 98 percent / CuI; CsOAc / dimethylsulfoxide / 24 h / 23 °C
4: 99 percent / H2 / Pd/C / ethyl acetate; ethanol / 3 h / 23 °C
5: 89 percent / aq. KOH / methanol / 1 h / Heating
6: SOCl2; DMF / toluene / 0.33 h / 70 °C
View Scheme
参考文献
Yamada, Ken; Kurokawa, Toshiki; Tokuyama, Hidetoshi; Fukuyama, Tohru
Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6630 - 6631
反应条件
1: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1 h, 2) -78 deg C, 1 h
2: 79 percent / triethylsilane / trifluoroacetic acid / Ambient temperature
View Scheme
参考文献
Ple; Turck; Martin; Barbey; Queguiner
Tetrahedron Letters, 1993 , vol. 34, # 10 p. 1605 - 1608
反应条件
1: NaBH4 / methanol
2: pyridine / benzene / Ambient temperature
3: 15 percent Chromat. / Irradiation
View Scheme
参考文献
Pincock, J. A.; Wedge, P. J.
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5587 - 5595
反应条件
manganese(IV) oxide; sodium cyanide in chloroform; isopropyl alcohol
T=20°C; Gilman oxidation; 2 h;
参考文献
Keck, Gary E; McLaws, Mark D; Wager, Travis T
Tetrahedron, 2000 , vol. 56, # 51 p. 9875 - 9883
反应条件
1.1: Mg / diethyl ether
1.2: 79 percent / toluene; diethyl ether / 14 h / 20 °C
2.1: 89 percent / DDQ / dioxane / 14 h / 20 °C
View Scheme
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 92, p. 200
反应条件
(i) Et2O, (ii) CrO3, aq. H2SO4, acetone; Multistep reaction;
参考文献
Barata,L.E.S. et al.
Phytochemistry (Elsevier), 1978 , vol. 17, p. 783 - 786
反应条件
Ni-Al hydrotalcite in various solvent(s)
T=50°C; Knoevenagel condensation; 3 h;
参考文献
Khan, Faiz Ahmed; Dash, Jyotirmayee; Satapathy, Rashmirekha; Upadhyay, Sarasij K.
Tetrahedron Letters, 2004 , vol. 45, # 15 p. 3055 - 3058
反应条件
1: With acetic acid in acetonitrile
0.166667 h;
2: With ammonium acetate in acetonitrile
T=80°C; 8 h;
参考文献
Borate, Hanumant B.; Gaikwad, Supriya H.; Kudale, Ananada S.; Chavan, Subhash P.; Pharande, Shrikant G.; Wagh, Vitthal D.; Sawant, Vikram S.
Tetrahedron Letters, 2013 , vol. 54, # 12 p. 1528 - 1530
反应条件
1: With acetic acid in acetonitrile
0.166667 h;
2: With ammonium acetate in acetonitrile
T=80°C; 8 h;
参考文献
Borate, Hanumant B.; Gaikwad, Supriya H.; Kudale, Ananada S.; Chavan, Subhash P.; Pharande, Shrikant G.; Wagh, Vitthal D.; Sawant, Vikram S.
Tetrahedron Letters, 2013 , vol. 54, # 12 p. 1528 - 1530
反应条件
H-Y zeolite in hexane
1.5 h; Heating;
参考文献
Kumar; Reddy; Singh; Pandey
Synthesis, 1993 , # 1 p. 67 - 69
