3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
sulfuric acid; nitric acid
T=20°C; Cooling with ice;
参考文献
Hanson, James R.; Hitchcock, Peter B.; Toche, Francois
Journal of Chemical Research, 2008 , # 8 p. 476 - 478
反应条件
1: alcohol; KOH-solution / -5 °C / Behandeln des Reaktionsprodukts mit verd. Salzsaeure
2: zinc; sodium amalgam; glacial acetic acid / Reagens4: Alkohol
3: methanol / 100 °C
View Scheme
参考文献
Spaeth
Monatshefte fuer Chemie, 1919 , vol. 40, p. 138
Monatshefte fuer Chemie, 1921 , vol. 42, p. 263
反应条件
ammonium acetate
T=90°C; Henry reaction; 0.416667 h; Microwave irradiation;
参考文献
Rodriguez, Jose M.; Dolors Pujol
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2629 - 2632
反应条件
ammonium acetate
T=60°C; Henry reaction; 0.75 h; Ultrasound irradiation;
参考文献
Rodriguez, Jose M.; Dolors Pujol
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2629 - 2632
反应条件
1.1: 100 percent / potassium tert-butoxide / 4.5 h / 100 °C
2.1: 73 percent / triflic acid / CH2Cl2 / 4 h
3.1: silica; H2O
3.2: CH2Cl2
View Scheme
参考文献
Aranda,G.
Chimica Therapeutica, 1971 , vol. 6, p. 262 - 267
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 92, p. 200
Full Text Show Details
Spaeth
Monatshefte fuer Chemie, 1919 , vol. 40, p. 138
Monatshefte fuer Chemie, 1921 , vol. 42, p. 263
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Inert atmosphere
2.1: water; potassium hydroxide / tetrahydrofuran / Inert atmosphere
3.1: potassium carbonate / acetone / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere
4.2: Inert atmosphere
View Scheme
参考文献
Caldwell, Stuart T.; McPhail, Donald B.; Duthie, Garry G.; Hartley, Richard C.
Canadian Journal of Chemistry, 2012 , vol. 90, # 1 p. 23 - 33
反应条件
anhydrous magnesium perchlorate in 1,2-dichloro-ethane
T=20°C;
参考文献
Chakraborti, Asit K.; Bhagat, Srikant; Rudrawar, Santosh
Tetrahedron Letters, 2004 , vol. 45, # 41 p. 7641 - 7644
反应条件
sodium acetate in ethanol; water
T=20 - 80°C;
参考文献
Guru, Murali Mohan; Ali, Md Ashif; Punniyamurthy, Tharmalingam
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5295 - 5308
反应条件
1: I2, AgO2CCF3 / CH2Cl2 / 12 h / 20 °C
2: NaBH4 / methanol / 0.5 h / -5 °C
View Scheme
参考文献
Bradley, Adrian; Motherwell, William B.; Ujjainwalla, Feroze
Chemical Communications, 1999 , # 10 p. 917 - 918
