5-疏基-1-苯基-四氮唑合成路线 （共 82 条）
反应条件
1.1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 90 °C
2.1: toluene / 80 °C
3.1: zinc; methanesulfonic acid / tetrahydrofuran / |Inert atmosphere; |Reflux
3.2: 50 - 60 °C
4.1: diethyl methoxy borane / tetrahydrofuran / 1 h / -70 - -60 °C / |Inert atmosphere
4.2: 3 h / -70 - 60 °C / |Inert atmosphere
5.1: methanesulfonic acid / acetone / 3 h / 20 °C
6.1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol; water / 20 - 50 °C
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参考文献
SUNSHINE LAKE PHARMA CO., LTD.; YICHANG CHANGJIANG PHARMACEUTICAL CO., LTD.; ZHANG, Shouhua; WANG, Zhongqing; LUO, Zhonghua
Patent: WO2013/10488 A1, 2013 ;
反应条件
1: PPh3; DIAD / tetrahydrofuran / 4 h / 20 °C
2: 877 mg / aq. H2O2 / (NH4)6Mo7O24 / ethanol / 6 h / 20 °C
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参考文献
Pospisil, Jiri; Marko, Istvan E.
Organic Letters, 2006 , vol. 8, # 26 p. 5983 - 5986
