1: With triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in toluene
T=110°C; Stille coupling reaction;
2: With hydrogenchloride in toluene
T=20°C; 12 h;
1: NH2OH*HCl, K2CO3 / methanol / 3 h / 60 °C
2: 63 percent / silver carbonate on celite / CHCl3 / 3 h / Ambient temperature; in the dark
3: 56 percent / CH2Cl2 / 2 h
View Scheme
参考文献
Demeunyck, Martine; Tohme, Najat; Lhomme, Marie-France; Lhomme, Jean
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 501 - 503
Pretorius, Stefan I.; Breytenbach, Wilma J.; De Kock, Carmen; Smith, Peter J.; N'Da, David D.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 269 - 277