2-(苄氧基)-5-溴苯甲酸甲酯合成路线 (共 2 条)
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in dichloromethane
T=20°C; 16.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/73205 A1, 2005 ;
Location in patent: Page/Page column 68 ;
WO 2005/073205 A1
反应条件
potassium carbonate in acetone
19 h; RefluxInert atmosphere;
参考文献
Xia, Zebin; Correa, Ricardo G.; Das, Jayanta K.; Farhana, Lulu; Castro, David J.; Yu, Jinghua; Oshima, Robert G.; Fontana, Joseph A.; Reed, John C.; Dawson, Marcia I.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 233 - 249