8-溴-2,3-二氢苯并[b][1,4]二噁英-6-甲醛合成路线 （共 4 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=100°C; 20 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/49609 A1, 2007 ;
Location in patent: Page/Page column 101 ;
US 20070049609 A1
反应条件
1: 5-bromo-3,4-dihydroxybenzaldehyde With caesium carbonate in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: ethylene dibromide in N,N-dimethyl-formamide
T=80°C; 4 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122258 A1, 2007 ;
Location in patent: Page/Page column 45 ;
反应条件
1: 83 percent / AlCl3; pyridine / CHCl3 / 24 h / Heating
2: 35 percent / Na2CO3; CuO / dimethylformamide / 4 h / 120 - 130 °C
View Scheme
参考文献
Vallejos, Gabriel; Fierro, Angelica; Rezende, Marcos Caroli; Sepulveda-Boza, Silvia; Reyes-Parada, Miguel
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 14 p. 4450 - 4457
反应条件
1: 54 percent / Br2; AcOH
2: 83 percent / AlCl3; pyridine / CHCl3 / 24 h / Heating
3: 35 percent / Na2CO3; CuO / dimethylformamide / 4 h / 120 - 130 °C
View Scheme
参考文献
Vallejos, Gabriel; Fierro, Angelica; Rezende, Marcos Caroli; Sepulveda-Boza, Silvia; Reyes-Parada, Miguel
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 14 p. 4450 - 4457
