1: With lithium hydroxide hydrate; water in tetrahydrofuran T=20°C; 3 h; 2: With hydrogenchloride in tetrahydrofuran; water

tetrabutyl ammonium fluoride in diethyl ether T=25°C; 20 h;

1.1: N,N-dimethylethanolamine; BuLi / hexane / 0.75 h / -75 °C 1.2: 62 percent / diethyl ether; hexane 2.1: 84 percent / tetrabutylammonium fluoride trihydrate / diethyl ether / 20 h / 25 °C View Scheme

1.1: 2,2,6,6-tetramethylpiperidine; BuLi / tetrahydrofuran; hexane / 2 h / -75 °C 1.2: tetrahydrofuran; hexane / 2 h / -75 °C 2.1: 15.2 g / 1,1,2-trichloro-1,2,2-trifluoroethane; BuLi / tetrahydrofuran; hexane / -75 °C 3.1: N,N-dimethylethanolamine; BuLi / hexane / 0.75 h / -75 °C 3.2: 62 percent / diethyl ether; hexane 4.1: 84 percent / tetrabutylammonium fluoride trihydrate / diethyl ether / 20 h / 25 °C View Scheme

1.1: 15.2 g / 1,1,2-trichloro-1,2,2-trifluoroethane; BuLi / tetrahydrofuran; hexane / -75 °C 2.1: N,N-dimethylethanolamine; BuLi / hexane / 0.75 h / -75 °C 2.2: 62 percent / diethyl ether; hexane 3.1: 84 percent / tetrabutylammonium fluoride trihydrate / diethyl ether / 20 h / 25 °C View Scheme

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 15 h / 20 °C 2: trichlorophosphate / 4 h / Reflux; Inert atmosphere 3: water; lithium hydroxide hydrate / tetrahydrofuran / 3 h / 20 °C View Scheme

1: trichlorophosphate / 4 h / Reflux; Inert atmosphere 2: water; lithium hydroxide hydrate / tetrahydrofuran / 3 h / 20 °C View Scheme

ammonium formate; palladium on activated charcoal in methanol T=50°C; 6 h;