in tetrahydrofuran T=20 - 80°C; 2.08333 h;

1: With potassium carbonate in N,N-dimethyl-formamide T=20°C; 72 h; 2: With lithium hydroxide in tetrahydrofuran; methanol; water T=50°C; 1 h; 3: With hydrogenchloride in tetrahydrofuran; methanol; water T=20°C; pH=4;