N'-芴甲氧羰基-N-苄氧羰基-L-赖氨酸合成路线 (共 5 条)
反应条件
1: N6-[(phenylmethoxy)carbonyl]-L-lysine With sodium hydrogencarbonate in tetrahydrofuran; water 2: (9H-Fluoren-9-yl)-methyl chloroformate in tetrahydrofuran; water T=0°C; 3: With hydrogenchloride in tetrahydrofuran; water pH=2 - 3;
参考文献
Huhtiniemi, Tero; Salo, Heikki S.; Suuronen, Tiina; Poso, Antti; Salminen, Antero; Leppaenen, Jukka; Jarho, Elina; Lahtela-Kakkonen, Maija
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6456 - 6468
反应条件
sodium hydrogencarbonate in water; acetone Ambient temperature;
参考文献
Schoen, Istvan; Kisfaludy, Lajos
Synthesis, 1986 , # 4 p. 303 - 305
参考文献
Kisfaludy, Lajos; Schoen, Istvan
Synthesis, 1983 , # 4 p. 325 - 327
反应条件
thionyl chloride in dichloromethane 0.5 h; Heating; Yield given;
参考文献
Beyermann, Michael; Bienert, Michael; Niedrich, Hartmut; Carpino, Louis A.; Sadat-Aalaee, Dean
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 721 - 728
反应条件
trifluorormethanesulfonic acid; 3-methyl-phenol; trifluoroacetic acid T=4°C; 1 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 8 p. 1230 - 1233