FMOC-L-缬氨酸五氟苯酯合成路线 （共 10 条）
反应条件
dicyclohexyl-carbodiimide in ethyl acetate 0 deg C, 1 h; r.t., 1 h;
参考文献
Kisfaludy, Lajos; Schoen, Istvan
Synthesis, 1983 , # 4 p. 325 - 327
反应条件
pyridine in tetrahydrofuran T=4°C;
参考文献
Jacobsen, Mogens Havsteen; Buchardt, Ole; Engdahl, Tom; Holm, Arne
Tetrahedron Letters, 1991 , vol. 32, # 43 p. 6199 - 6202
反应条件
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; Esterification;
参考文献
Pudhom, Khanitha; Vilaivan, Tirayut
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5939 - 5942
反应条件
1: 83 percent / pyridine / 4 °C 2: 80 percent / HOBt; DIEA / dimethylformamide / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 32 p. 5939 - 5942
反应条件
1: SOCl2, pyridine / CH2Cl2 / Heating 2: 91 percent / pyridine / tetrahydrofuran / 4 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 43 p. 6199 - 6202
反应条件
1: 90 percent / NaHCO3 / H2O; acetone / Ambient temperature 2: dicyclohexylcarbodiimide / ethyl acetate / 2 h / 0 °C View Scheme
参考文献
Synthesis, , # 4 p. 303 - 305
反应条件
1: 90 percent / NaHCO3 / H2O; acetone / Ambient temperature 2: dicyclohexylcarbodiimide / ethyl acetate / 2 h / 0 °C View Scheme
参考文献
Synthesis, , # 4 p. 303 - 305
反应条件
benzotriazol-1-ol; H2O in tetrahydrofuran; water T=20°C; 240 h;
参考文献
Riken
Patent: EP1757568 A1, 2007 ;
Location in patent: Page/Page column 7 ;
参考文献
Polish Journal of Chemistry, , vol. 66, # 8 p. 1269 - 1276
反应条件
Yield given. Multistep reaction;
参考文献
Deal, Martyn J.; Hagan, Russell M.; Ireland, Simon J.; Jordan, Christopher C.; McElroy, Andrew B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4195 - 4204
