1-n-boc-5-溴-2,3-二氢-1H-吲哚-7-羧酸甲酯合成路线 （共 9 条）
反应条件
1: trifluoroacetic acid / 20 °C 2: manganese(IV) oxide / tetrahydrofuran / 20 °C View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
WO 2008/118724 A1
反应条件
N-bromosuccinmide in dichloromethane
T=20°C; Inert atmosphere; Product distribution / selectivity;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
Location in patent: Page/Page column 68 ;
WO 2008/118724 A1
反应条件
1.1: tetrahydrofuran / 20 °C
2.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / -78 °C
2.2: -78 °C
3.1: N-bromosuccinmide / dichloromethane / 20 °C
View Scheme
参考文献
Miller, David D.; Bamborough, Paul; Christopher, John A.; Baldwin, Ian R.; Champigny, Aurelie C.; Cutler, Geoffrey J.; Kerns, Jeffrey K.; Longstaff, Timothy; Mellor, Geoffrey W.; Morey, James V.; Morse, Mary A.; Nie, Hong; Rumsey, William L.; Taggart, John J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2255 - 2258
反应条件
1.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / -78 °C
1.2: -78 °C
2.1: N-bromosuccinmide / dichloromethane / 20 °C
View Scheme
参考文献
Miller, David D.; Bamborough, Paul; Christopher, John A.; Baldwin, Ian R.; Champigny, Aurelie C.; Cutler, Geoffrey J.; Kerns, Jeffrey K.; Longstaff, Timothy; Mellor, Geoffrey W.; Morey, James V.; Morse, Mary A.; Nie, Hong; Rumsey, William L.; Taggart, John J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2255 - 2258
反应条件
1.1: tetrahydrofuran / 20 °C
2.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / -78 °C
2.2: -78 °C
3.1: N-bromosuccinmide / dichloromethane / 20 °C
View Scheme
参考文献
Miller, David D.; Bamborough, Paul; Christopher, John A.; Baldwin, Ian R.; Champigny, Aurelie C.; Cutler, Geoffrey J.; Kerns, Jeffrey K.; Longstaff, Timothy; Mellor, Geoffrey W.; Morey, James V.; Morse, Mary A.; Nie, Hong; Rumsey, William L.; Taggart, John J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2255 - 2258
反应条件
1.1: sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere
2.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; diethyl ether / 1.67 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
2.2: 1 h / -78 - 20 °C / Inert atmosphere
3.1: N-bromosuccinmide / dichloromethane / 20 °C / Inert atmosphere
View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
WO 2008/118724 A1
反应条件
trifluoroacetic acid
T=20°C; 16 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
Location in patent: Page/Page column 68-69 ;
WO 2008/118724 A1
反应条件
1: trifluoroacetic acid / 20 °C
2: manganese(IV) oxide / tetrahydrofuran / 20 °C
3: methanol; lithium hydroxide hydrate / Heating
View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
WO 2008/118724 A1
反应条件
1: trifluoroacetic acid / 20 °C
2: manganese(IV) oxide / tetrahydrofuran / 20 °C
3: methanol; lithium hydroxide hydrate / Heating
4: HATU; ammonia; N-ethyl-N,N-diisopropylamine / 1,4-dioxane; dichloromethane / 20 °C
View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
WO 2008/118724 A1
