2-氨基-5-碘噻唑-4-羧酸乙酯合成路线 (共 2 条)
反应条件
N-iodo-succinimide in dichloromethane
T=20°C; 24 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00362 ;
反应条件
tBuONO in tetrahydrofuran
T=50°C;
参考文献
Hodgetts, Kevin J.; Blum, Charles A.; Caldwell, Timothy; Bakthavatchalam, Rajagopal; Zheng, Xiaozhang; Capitosti, Scott; Krause, James E.; Cortright, Daniel; Crandall, Marci; Murphy, Beth Ann; Boyce, Susan; Brian Jones; Chenard, Bertrand L.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4359 - 4363