(R)-(-)-3-羟基四氢呋喃合成路线 （共 14 条）
反应条件
strong acid ion exchange resin (Amberlyst 15, H+ form) in 1,4-dioxane T=100°C; P=760.051 Torr; Product distribution / selectivity;
参考文献
SK CORPORATION
Patent: WO2007/81065 A1, 2007 ;
Location in patent: Page/Page column 6-7 ;
反应条件
hydrogenchloride; sodium hydroxide in methanol; water
参考文献
Takasago International Corporation
Patent: US5780649 A1, 1998 ;
参考文献
Piccolo, Oreste; Castagnani, Roberto; De Witt, Paolo
Patent: US2003/32818 A1, 2003 ;
反应条件
K2OsO4*2H2O; methanesulfonamide; water; potassium carbonate; (DHQ)2-PHAL; potassium hexacyanoferrate(III) in tert-butyl alcohol T=0°C; Sharpless asymmetric dihydroxylation; 6 h; optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 11-12 p. 898 - 903
反应条件
EL-14 lipase in hexane T=4°C; 16 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 8 p. 583 - 586
反应条件
vinyl acetate; Candida antarctica B lipase on carrier C3 in hexane T=37°C; 0.0833333 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 23 p. 4781 - 4790
反应条件
sodium phosphate buffer; esterase B from Candida antarctica in water T=37°C; pH=7.3; 1 h; Product distribution;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 22 p. 4201 - 4204
反应条件
crude extract of Escherichia coli DH5α cells containing Bacillus stearothermophilus esterase, V224Y mutant in aq. phosphate buffer T=37°C; pH=7.5; 42 h; Enzymatic reaction; Reagent/catalyst; enantioselective reaction;
参考文献
FEBS Journal, , vol. 280, # 13 p. 3084 - 3093
参考文献
Heterocycles, , vol. 28, # 1 p. 283 - 294
反应条件
Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 108, # 8 p. 2049 - 2054
