2-溴-5-甲基-4-硝基苯甲醚合成路线 （共 7 条）
反应条件
1: iron; methanol; aqueous hydrochloric acid 2: Diazotization View Scheme
参考文献
Kermack; Wight
Journal of the Chemical Society, 1935 , p. 1425
反应条件
N-bromosuccinmide in acetonitrile
T=140°C; Sealed tube;
参考文献
Lankalapalli, Ravi S.; Ouro, Alberto; Arana, Lide; Gomez-Munoz, Antonio; Bittman, Robert
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8844 - 8847
反应条件
1: 3-hydroxy-6-nitro-toluene With bromine; acetic acid
2: methyl iodide With potassium carbonate in acetone
T=20°C; Reflux;
参考文献
TAKEDA SAN DIEGO, INC.
Patent: US2009/286800 A1, 2009 ;
Location in patent: Page/Page column 109-111 ;
US 20090286800 A1
反应条件
1: chloroform; bromine / 40 - 50 °C
2: K2CO3; benzene
View Scheme
参考文献
Kermack; Wight
Journal of the Chemical Society, 1935 , p. 1425
反应条件
potassium carbonate; benzene
参考文献
Kermack; Wight
Journal of the Chemical Society, 1935 , p. 1425
反应条件
(i) Br2, BrCH2CH2Br, (ii) /BRN= 635994/, benzene; Multistep reaction;
参考文献
Muntwyler; Widmer; Keller-Schierlein
Helvetica chimica acta, 1970 , vol. 53, # 6 p. 1544 - 1547
反应条件
hydrogenchloride; methanol; iron
参考文献
Kermack; Wight
Journal of the Chemical Society, 1935 , p. 1425
