2,6-二氯-4-甲氧基苯甲醇合成路线 （共 9 条）
反应条件
1: MnO2 / benzene / Heating 2: BBr3 / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
反应条件
1: With hydrogenchloride; sulfuric acid in water
T=60°C;
2: With sodium hydroxide in 1,4-dioxane; water
3 h; Heating;
参考文献
WYETH
Patent: WO2004/99122 A2, 2004 ;
Location in patent: Page 18; 35 ;
WO 2004/099122 A2
反应条件
1: With sodium tetrahydroborate in ethanol
T=7°C; 2 h;
2: With water; ammonium chloride in ethanol
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/127688 A2, 2007 ;
Location in patent: Page/Page column 28 ;
Title/Abstract Full Text Show Details
ELI LILLY AND COMPANY
Patent: WO2007/127704 A1, 2007 ;
Location in patent: Page/Page column 28 ;
WO 2007/127704 A1
反应条件
lithium aluminium tetrahydride in diethyl ether
T=0°C; 3 h;
参考文献
Pascal, Robert A.; Chen, Y.-C. Jack
Journal of Organic Chemistry, 1985 , vol. 50, # 3 p. 408 - 410
反应条件
sodium hydroxide in 1,4-dioxane; water
3 h; Heating / reflux;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1864971 A1, 2007 ;
Location in patent: Page/Page column 134-135 ;
EP 1864971 A1
反应条件
1: 1.) n-BuLi, TMEDA, 3.) SOCl2, 4.) pyridine
2: 90 percent / LiAlH4 / diethyl ether / 3 h / 0 °C
View Scheme
参考文献
Pascal, Robert A.; Chen, Y.-C. Jack
Journal of Organic Chemistry, 1985 , vol. 50, # 3 p. 408 - 410
反应条件
sodium hydroxide in 1,4-dioxane
3 h; Heating; Yield given;
参考文献
Karl, Johann; Gust, Ronald; Spruss, Thilo; Schneider, Martin R.; Schoenenberg, Helmut; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 72 - 83
反应条件
1: With hydrogenchloride; sulfuric acid in water
T=70°C; 7 h; Inert atmosphere;
2: With sodium hydroxide in 1,4-dioxane; water
7 h; RefluxInert atmosphere;
参考文献
Tietze, Lutz F.; Vock, Carsten A.; Krimmelbein, Ilga K.; Nacke, Linda
Synthesis, 2009 , # 12 art. no. T20108SS, p. 2040 - 2060
反应条件
1: MnO2 / benzene / Heating
2: BBr3 / CH2Cl2 / 0 - 20 °C
3: 87 percent / pyridine / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
