(R)-2-苄基-DL-脯氨酸盐酸盐合成路线 （共 7 条）
反应条件
1: With hydrogenchloride; water T=140°C; 72 h; 2: With methyloxirane in ethanol 0.5 h; Reflux;
参考文献
Tuzina, Pavel; Somfai, Peter
Organic Letters, 2009 , vol. 11, # 4 p. 919 - 921
反应条件
hydrogen bromide 12 h; Heating;
参考文献
Seebach,D.; Boes,M.; Naef,R.
Journal of the American Chemical Society, 1983 , vol. 105, p. 5390
反应条件
hydrogenchloride T=140°C; 72 h;
参考文献
MacQuarrie-Hunter, Stephanie; Carlier, Paul R.
Organic Letters, 2005 , vol. 7, # 23 p. 5305 - 5308
反应条件
1: 91 percent / tetrahydrofuran; hexane / -78 deg C -> -30 deg C, 2 h 2: 77 percent / 48percent aq. HBr / 12 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 105, p. 5390
反应条件
1: 89 percent / LDA / tetrahydrofuran; hexane / -100 °C 2: 85 percent / aq. HCl / 72 h / 140 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 23 p. 5305 - 5308
反应条件
1: 82 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C 2: 89 percent / LDA / tetrahydrofuran; hexane / -100 °C 3: 85 percent / aq. HCl / 72 h / 140 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 23 p. 5305 - 5308
反应条件
1: (R)-2-benzylpyrrolidine-2-carboxylic acid With tetreamethyl ammonium hydroxide in acetonitrile 1.5 h; 2: di-tert-butyl dicarbonate in acetonitrile 72 h;
参考文献
US2008/146607 A1, ;
Page/Page column 95-96 ;
