2,4-二氯-6-甲基吡啶-3-甲酸乙酯合成路线 （共 16 条）
反应条件
1: With 1-[N,N-bis-(2-hydroxyethyl)amino]-2-propanol; trichlorophosphate T=0 - 25°C; 20 h; 2: With sodium carbonate in water T=0°C; pH=8;
参考文献
Pfizer Inc.
Patent: US2009/54395 A1, 2009 ;
Location in patent: Page/Page column 44 ;
反应条件
trichlorophosphate 1 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 9 p. 1329 - 1333
反应条件
1: 76 percent / NaOEt / ethanol / 17 h / 140 - 160 °C 2: 59 percent / POCl3; NEt3 / 2 h / Heating View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 342, # 1 p. 33 - 39
反应条件
trichlorophosphate T=130°C;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 65, p. 10,13
反应条件
1: 76 percent / Na / 3 h / 60 °C 2: 74 percent / KOAc, H2 / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
sodium methylate in methanol T=0 - 60°C; 5 h;
参考文献
Pfizer Inc.
Patent: US2009/54395 A1, 2009 ;
Location in patent: Page/Page column 44 ;
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
1: palladium; potassium acetate; ethanol / Hydrogenation 2: aqueous KOH View Scheme
参考文献
Kooyman; Wibaut
Recueil des Travaux Chimiques des Pays-Bas, 1946 , vol. 65, p. 10,13
反应条件
1: 83 percent / Na / 3 h / 60 °C 2: 81 percent / KOAc, H2 / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr 3: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
ethanol; potassium acetate; palladium Hydrogenation;
参考文献
Kooyman; Wibaut
Recueil des Travaux Chimiques des Pays-Bas, 1946 , vol. 65, p. 10,13
