2,4-二氯-6-甲基吡啶-3-甲酸乙酯合成路线 （共 16 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=-78 - -30°C; 6 h;
2: With water; sodium hydroxide in tetrahydrofuran
T=-30 - 20°C;
参考文献
MEDICAL RESEARCH COUNCIL TECHNOLOGY; CHAN, Brayn; ESTRADA, Anthony; SWEENEY, Zachary; MCIVER, Edward Giles
Patent: WO2011/141756 A1, 2011 ;
Location in patent: Page/Page column 50-51 ;
WO 2011/141756 A1
反应条件
AMINOHIPPURATE SODIUM in ethanol
参考文献
ACTELION PHARMACEUTICALS LTD.; Hilpert, Kurt; Hubler, Francis; Kimmerlin, Thierry; Renneberg, Dorte; Stamm, Simon; Murphy, Mark
Patent: US2014/163035 A1, 2014 ;
Location in patent: Page/Page column ;
参考文献
ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon
Patent: WO2013/14587 A1, 2013 ;
Location in patent: Page/Page column 79 ;
WO 2013/014587 A1
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
1: LAH / tetrahydrofuran / 7 h / -78 - -30 °C
2: 5.00 g / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -70 - 20 °C
View Scheme
参考文献
MEDICAL RESEARCH COUNCIL TECHNOLOGY; CHAN, Brayn; ESTRADA, Anthony; SWEENEY, Zachary; MCIVER, Edward Giles
Patent: WO2011/141756 A1, 2011 ;
WO 2011/141756 A1
反应条件
1: With sodium hydroxide in methanol; water
T=80°C; 4 h;
2: With sulfuric acid in methanol; water
参考文献
Wang, Yamin; Bullock, William H.; Chen, Libing
Patent: US6677352 B1, 2004 ;
Location in patent: Page/Page column 60; 85 ;
