1: trifluoroacetic acid / H2O / 6 h / 20 °C 2: 5.84 g / pyridine; 4-(dimethylamino)pyridine / 40 h / 20 °C 3: 71 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 24 h / 60 °C 4: 74 percent / NH3 / methanol / 46 h / 20 °C View Scheme

1: trifluoroacetic acid / H2O / 6 h / 20 °C 2: 5.84 g / pyridine; 4-(dimethylamino)pyridine / 40 h / 20 °C 3: 90 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 21 h / 60 °C 4: 77 percent / NH3 / methanol / 46 h / 20 °C View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1: acetic acid / H₂O / 24 h / 20 &deg;C<br />2: sodium periodate / methanol; H₂O / 15 h / 20 &deg;C<br />3: 7.17 g / sodium borohydride / methanol / 6.5 h / 20 &deg;C<br />4: pyridine; 4-(dimethylamino)pyridine / 5 h / 20 &deg;C<br /> <br /> &nbsp;