4-甲氧基-3-[3-(4-吗啉基)丙氧基]苯甲醛合成路线 （共 5 条）
反应条件
nitric acid in water T=40 - 45°C; 4.33333 - 4.5 h;
参考文献
NATCO PHARMA LIMITED; JYOTHI PRASAD, Ramanadham; PULLA REDDY, Muddasani; NAGESHWARA RAO, Bollepalli; VENKAIAH CHOWDARY, Nannapaneni
Patent: WO2005/70909 A1, 2005 ;
Location in patent: Page/Page column 24-25 ;
反应条件
1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 2: 349 g / acetic anhydride / 3 h / 110 °C 3: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C View Scheme
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 2.1: 349 g / acetic anhydride / 3 h / 110 °C 3.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 86 percent / HCl / H2O / 90 - 130 °C 5.1: thionyl chloride / dimethylformamide / 2 h / Heating 5.2: 73 percent / dimethylformamide / 1 h / 100 °C View Scheme
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 2.1: 349 g / acetic anhydride / 3 h / 110 °C 3.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=100°C; 3 h;
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
