E-5-(2-羰基甲氧基乙烯基)-2’-脱氧尿苷合成路线 （共 8 条）
反应条件
palladium diacetate; triethylamine; triphenylphosphine in 1,4-dioxane 14 h; Heating;
参考文献
Rong; Soloway
Nucleosides and Nucleotides, 1994 , vol. 13, # 9 p. 2021 - 2034
反应条件
palladium diacetate in acetonitrile 32 h; Heating;
参考文献
Hirota, Kosaku; Isobe, Yoshiaki; Kitade, Yukio; Maki, Yoshifumi
Synthesis, 1987 , # 5 p. 495 - 496
反应条件
in acetonitrile 24 h; Irradiation;
参考文献
Hassan, Mohamed E.
Recueil des Travaux Chimiques des Pays-Bas, 1986 , vol. 105, # 1 p. 30 - 32
反应条件
1: Ambient temperature 2: 41 percent / acetonitrile / 24 h / Irradiation View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 105, # 1 p. 30 - 32
反应条件
sodium hydroxide in methanol 2 h;
参考文献
Rong; Soloway
Nucleosides and Nucleotides, 1994 , vol. 13, # 9 p. 2021 - 2034
反应条件
1: 65 percent / 1M aq. NaOH / 40 h / 20 °C 2: 68 percent / N-bromosuccinimide, potassium carbonate / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Ashwell, Mark; Jones, A. Stanley; Kumar, Ajit; Sayers, Jon R.; Walker, Richard T.; et. al.
Tetrahedron, 1987 , vol. 43, # 20 p. 4601 - 4608
反应条件
1: sodium hydroxide / water
2: diisopropyl-carbodiimide / N,N-dimethyl-formamide / 4 h / 25 °C
View Scheme
参考文献
RIKEN; Okamoto, Akimitsu; Ikeda, Shuji
Patent: US2013/289263 A1, 2013 ;
反应条件
1: H2 / 5percent Pd/C / methanol / 15 h / 2250.2 Torr
2: 1.) hexamethyldisilazane, trimethylchlorosilane, 2.) LiBH4 / 1.) reflux, 2h, 2.) ether, reflux, 4h
3: 1.) triphenylphosphine, 2.) carbon tetrachloride, pyridine / 1.) DMF, 10 min, 2.) DMF, RT, 1.5 h
View Scheme
参考文献
Griengl, Herfried; Bodenteich, Michael; Hayden, Walter; Wanek, Erich; Streicher, Wolfgang; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1679 - 1684
