1: With n-butyllithium in tetrahydrofuran; pentane
T=-78°C; 0.216667 h;
2: With tri-isopropoxy-borane in tetrahydrofuran; pentane
T=-78°C; 0.666667 h;
3: With lithium hydroxide; water in tetrahydrofuran; pentane
T=20°C; 2 h;
参考文献
Sutton, James C.; Pi, Zulan; Ruel, Rejean; L'Heureux, Alexandre; Thibeault, Carl; Lam, Patrick Y. S.
Patent: US2006/173002 A1, 2006 ;
Location in patent: Page/Page column 77 ;
US 20060173002 A1
1: 2-(2-tert-Butylphenoxy)-3-iodopyridine With n-butyllithium in tetrahydrofuran; pentane
T=-78°C; 0.216667 h;
2: tri-isopropoxy-borane in tetrahydrofuran; pentane
T=-78°C; 0.666667 h;
3: With hydrogenchloride; lithium hydroxide
more than 3 stages;
参考文献
Bristol-Myers Squibb Company
Patent: US2006/293522 A1, 2006 ;
Location in patent: Page/Page column 19 ;
US 20060293522 A1
