D-(+)-(2-氯苯)甘氨酸合成路线 （共 8 条）
反应条件
1: With ammonium hydrogen carbonate in methanol; water T=65 - 70°C; 5 h; 2: With sodium hydroxide in methanol; water T=120°C; 4 h; 3: With sulfuric acid in methanol; water pH=7 - 8;
参考文献
Robert C. C. Wu
Patent: US2004/176637 A1, 2004 ;
Location in patent: Page 3 ;
参考文献
Journal of the Chemical Society, , p. 1440 - 1444
反应条件
tris-(2-chloro-ethyl)-amine; sulfuric acid; benzene
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 7, p. 912,914, 916
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; 18 h;
参考文献
Ferraboschi, Patrizia; Mieri, Maria De; Galimberti, Fiorella
Tetrahedron Asymmetry, 2010 , vol. 21, # 17 p. 2136 - 2141
反应条件
thionyl chloride T=20°C; Heating;
参考文献
Van Der Meijden, Maarten W.; Leeman, Michel; Gelens, Edith; Noorduin, Wim L.; Meekes, Hugo; Van Enckevort, Willem J.P.; Kaptein, Bernard; Vlieg, Elias; Kellogg, Richard M.
Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1195 - 1198
反应条件
thionyl chloride T=20°C; Heating;
参考文献
Van Der Meijden, Maarten W.; Leeman, Michel; Gelens, Edith; Noorduin, Wim L.; Meekes, Hugo; Van Enckevort, Willem J.P.; Kaptein, Bernard; Vlieg, Elias; Kellogg, Richard M.
Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1195 - 1198
反应条件
hydrogenchloride T=130°C;
参考文献
Pharmazie, , vol. 45, # 7 p. 529 - 530
反应条件
hydrogen bromide; sodium nitrite in water T=0°C; 7.33333 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/86264 A1, 2009 ;
Location in patent: Page/Page column 243 ;
WO 2009/086264 A1
