3,3'-双(亚乙基硫代)二丙腈合成路线 （共 7 条）
反应条件
poly(ethylene glycol) 2000; ruthenium trichloride T=50°C; Michael addition; 12 h;
参考文献
Chahdoura, Faouzi; Pradel, Christian; Gomez, Montserrat
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3648 - 3660
反应条件
triethylamine in dichloromethane T=20°C; Alkylation; 4 h;
参考文献
Bridger, Gary J.; Skerlj, Renato T.; Padmanabhan, Sreenivasan; Martellucci, Stephen A.; Henson, Geoffrey W.; Struyf, Sofie; Witvrouw, Myriam; Schols, Dominique; De Clercq, Erik
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3971 - 3981
参考文献
Journal of the Chemical Society, , p. 1808
Journal of the Chemical Society, , vol. 117, p. 299
参考文献
Journal of the Chemical Society, , p. 1808
Journal of the Chemical Society, , vol. 117, p. 299
Chemische Berichte, , vol. 53, p. 1008
反应条件
borane-THF
Reduction; 24 h; Heating;
参考文献
Bridger, Gary J.; Skerlj, Renato T.; Padmanabhan, Sreenivasan; Martellucci, Stephen A.; Henson, Geoffrey W.; Struyf, Sofie; Witvrouw, Myriam; Schols, Dominique; De Clercq, Erik
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3971 - 3981
反应条件
1: BH3*THF / 24 h / Heating
2: NaOH / H2O; diethyl ether / 20 h / 20 °C
3: 42 percent / Cs2CO3 / dimethylformamide / 24 h / 65 °C
4: 98 percent / 3 percent sodium amalgam, Na2HPO4 / tetrahydrofuran; methanol / 44 h / Heating
View Scheme
参考文献
Bridger, Gary J.; Skerlj, Renato T.; Padmanabhan, Sreenivasan; Martellucci, Stephen A.; Henson, Geoffrey W.; Struyf, Sofie; Witvrouw, Myriam; Schols, Dominique; De Clercq, Erik
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3971 - 3981
参考文献
Davies
Journal of the Chemical Society, 1920 , vol. 117, p. 299
