3-氟-4-甲基-5-碘苯甲酸合成路线 （共 5 条）
反应条件
N-iodo-succinimide; trifluorormethanesulfonic acid T=0 - 20°C;
参考文献
WO2007/339 A1, ;
Page/Page column 53 ;
WO 2007/000339 A1
反应条件
N-iodo-succinimide; trifluorormethanesulfonic acid T=0°C; 6 h;
参考文献
WO2007/147103 A2, ;
Page/Page column 121 ;
WO 2007/147103 A2
反应条件
thionyl chloride
T=110°C; 1 h;
参考文献
J. URIACH Y COMPANIA S.A.
Patent: WO2007/339 A1, 2007 ;
Location in patent: Page/Page column 53 ;
WO 2007/000339 A1
反应条件
1: 3-fluoro-5-iodo-4-methylbenzoic acid With oxalyl dichloride in dichloromethane
T=0 - 20°C; 2 h;
2: anhydrous cyclopropylamine With triethylamine in dichloromethane
T=0 - 20°C; 3 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/110173 A2, 2006 ;
Location in patent: Page/Page column 77 ;
WO 2006/110173 A2
反应条件
thionyl chloride
T=80°C; 2 h;
参考文献
ALMIRALL, S.A.; AIGUADE BOSCH, Jose; CARRANCO MORUNO, Ines
Patent: WO2011/57757 A1, 2011 ;
WO 2011/057757 A1
