2,4-二溴-5-氟苯甲醚合成路线 （共 3 条）
反应条件
sodium hydroxide in water
Williamson reaction;
参考文献
Dabrowski, Marek; Kubicka, Joanna; Lulinski, Sergiusz; Serwatowski, Janusz
Tetrahedron, 2005 , vol. 61, # 27 p. 6590 - 6595
反应条件
1: 78 percent / Br2 / 20 °C
2: 90 percent / NaOH / H2O
View Scheme
参考文献
Dabrowski, Marek; Kubicka, Joanna; Lulinski, Sergiusz; Serwatowski, Janusz
Tetrahedron, 2005 , vol. 61, # 27 p. 6590 - 6595
反应条件
1: 2,4-dibromo-5-fluoroanisole With n-butyllithium in tetrahydrofuran; diethyl ether
T=-78°C; 0.25 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; diethyl ether
T=-78°C; 0.25 h;
参考文献
Dabrowski, Marek; Kubicka, Joanna; Lulinski, Sergiusz; Serwatowski, Janusz
Tetrahedron, 2005 , vol. 61, # 27 p. 6590 - 6595
