6,7-二氢-2-五氟苯基-5H-吡咯并[2,1-c][1,2,4]三唑鎓四氟硼酸盐合成路线 （共 3 条）
反应条件
1: pyrrolidin-2-one; pentafluorophenyl hydrazine With trimethyl-oxonium tetrafluoroborate in dichloromethane
T=20°C;
2: orthoformic acid triethyl ester in methanol
T=100°C; Further stages.;
参考文献
Thomson, Jennifer E.; Campbell, Craig D.; Concellon, Carmen; Duguet, Nicolas; Rix, Kathryn; Slawin, Alexandra M. Z.; Smith, Andrew D.
Journal of Organic Chemistry, 2008 , vol. 73, # 7 p. 2784 - 2791
参考文献
Kerr, Mark S.; Read De Alaniz, Javier; Rovis, Tomislav
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5725 - 5728
反应条件
1: pyrrolidin-2-one; trimethyl-oxonium tetrafluoroborate in dichloromethane
T=20°C; Inert atmosphere;
2: pentafluorophenyl hydrazine in dichloromethane
T=20°C; 4 h; Inert atmosphere;
3: orthoformic acid triethyl ester in chlorobenzene
T=130°C; 48 h;
参考文献
Vora, Harit U.; Lathrop, Stephen P.; Reynolds, Nathan T.; Kerr, Mark S.; De Alaniz, Javier Read; Rovis, Tomislav; Chennamadhavuni, Spandan; Davies, Huw M. L.
Organic Syntheses, 2010 , vol. 87, p. 350 - 361
