(S)-4-苯基-2-恶唑烷酮合成路线 （共 47 条）
反应条件
(R)-BTM; sodium sulfate; N-ethyl-N,N-diisopropylamine in chloroform T=20°C; 8.5 h;
参考文献
Birman, Vladimir
Patent: US2005/256150 A1, 2005 ;
Location in patent: Page/Page column 20 ;
反应条件
(R)-2-phenyl-1,2-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in chloroform T=0°C; 3.5 h; Title compound not separated from byproducts;
参考文献
Birman, Vladimir B.; Jiang, Hui; Li, Ximin; Guo, Lei; Uffman, Eric W.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6536 - 6537
反应条件
1: 4-phenyl-2-oxo-1,3-oxazolidine With n-butyllithium in tetrahydrofuran T=-78°C; Resolution of racemate; 2: (R)-pentafluorophenyl 2-phenylbutanoate in tetrahydrofuran T=-78°C; 0.0833333 h; Resolution of racemate; optical yield given as percent eediastereoselective reaction;
参考文献
Al Shaye, Najla; Eames, Jason
Tetrahedron Letters, 2010 , vol. 51, # 45 p. 5892 - 5895
反应条件
1: 4-phenyl-2-oxo-1,3-oxazolidine With (R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in 1,1-dimethylpropan-1-ol T=0°C; Resolution of racemate; 2: isobutyric anhydride in 1,1-dimethylpropan-1-ol 24 h; Resolution of racemate; Reagent/catalystTimeConcentrationTemperature; enantioselective reaction;
参考文献
Yang, Xing; Bumbu, Valentina D.; Liu, Peng; Li, Ximin; Jiang, Hui; Uffman, Eric W.; Guo, Lei; Zhang, Wei; Jiang, Xuntian; Houk; Birman, Vladimir B.
Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17605 - 17612
参考文献
Ishizuka, Tadao; Kimura, Koreichi; Ishibuchi, Seigo; Kunieda, Takehisa
Chemistry Letters, 1992 , # 6 p. 991 - 994
反应条件
(R)-BTM; sodium sulfate; N-ethyl-N,N-diisopropylamine in chloroform T=20°C; 8.5 h;
参考文献
Birman, Vladimir
Patent: US2005/256150 A1, 2005 ;
Location in patent: Page/Page column 20 ;
反应条件
(R)-2-phenyl-1,2-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in chloroform T=0°C; 3.5 h; Title compound not separated from byproducts;
参考文献
Birman, Vladimir B.; Jiang, Hui; Li, Ximin; Guo, Lei; Uffman, Eric W.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6536 - 6537
反应条件
1: 4-phenyl-2-oxo-1,3-oxazolidine With (R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in 1,1-dimethylpropan-1-ol T=0°C; Resolution of racemate; 2: isobutyric anhydride in 1,1-dimethylpropan-1-ol 24 h; Resolution of racemate; Reagent/catalystTimeConcentrationTemperature; enantioselective reaction;
参考文献
Yang, Xing; Bumbu, Valentina D.; Liu, Peng; Li, Ximin; Jiang, Hui; Uffman, Eric W.; Guo, Lei; Zhang, Wei; Jiang, Xuntian; Houk; Birman, Vladimir B.
Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17605 - 17612
参考文献
Ishizuka, Tadao; Kimura, Koreichi; Ishibuchi, Seigo; Kunieda, Takehisa
Chemistry Letters, 1992 , # 6 p. 991 - 994
反应条件
N-(2-Aminoethyl)aminomethyl polystyrene in tetrahydrofuran T=60°C;
参考文献
Katz, Steven J; Bergmeier, Stephen C
Tetrahedron Letters, 2002 , vol. 43, # 4 p. 557 - 559
