(S)-4-苯基-2-恶唑烷酮合成路线 （共 47 条）
反应条件
sodium methylate in tetrahydrofuran
12 h; Ambient temperature;
参考文献
Pirkle, William H.; Simmons, Kirk A.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2520 - 2527
反应条件
PhSeOSO3- in 1,2-dichloro-ethane
T=80°C; 22 h;
参考文献
Tiecco, Marcello; Testaferri, Lorenzo; Marini, Francesca; Temperini, Andrea; Bagnoli, Luana; Santi, Claudio
Synthetic Communications, 1997 , vol. 27, # 23 p. 4131 - 4140
反应条件
1.1: tetrahydrofuran / 2 h / 20 °C
1.2: 78 percent / hydroxylamine hydrochloride / pyridine / 6 h / 20 °C
2.1: 90 percent / triethylamine / diethyl ether / 12 h / 20 °C
3.1: 92 percent / K2CO3; tetrakis(triphenylacetate)dirhodium / CH2Cl2 / 6 h / 25 °C
View Scheme
参考文献
Lebel, Helene; Huard, Kim; Lectard, Sylvain
Journal of the American Chemical Society, 2005 , vol. 127, # 41 p. 14198 - 14199
反应条件
sodium t-butanolate in tetrahydrofuran
参考文献
Birman, Vladimir B.; Jiang, Hui; Li, Ximin; Guo, Lei; Uffman, Eric W.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6536 - 6537
反应条件
1: NaBH4; LiCl / tetrahydrofuran
2: t-BuONa / tetrahydrofuran
View Scheme
参考文献
Birman, Vladimir B.; Jiang, Hui; Li, Ximin; Guo, Lei; Uffman, Eric W.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6536 - 6537
反应条件
1: 90 percent / triethylamine / diethyl ether / 12 h / 20 °C
2: 92 percent / K2CO3; tetrakis(triphenylacetate)dirhodium / CH2Cl2 / 6 h / 25 °C
View Scheme
参考文献
Lebel, Helene; Huard, Kim; Lectard, Sylvain
Journal of the American Chemical Society, 2005 , vol. 127, # 41 p. 14198 - 14199
反应条件
1: 90 percent / HCl, H2 / 5percent Pd/C / ethanol / 2.5 h / 3102.9 Torr
2: 89 percent / pyridine / tetrahydrofuran / 3 h / -15 °C
3: 90 percent / NaOCH3 / tetrahydrofuran / 12 h / Ambient temperature
View Scheme
参考文献
Pirkle, William H.; Simmons, Kirk A.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2520 - 2527
反应条件
1: 92 percent / NH2OH*HCl, Na2CO3 / aq. ethanol / 24 h / Heating
2: 90 percent / HCl, H2 / 5percent Pd/C / ethanol / 2.5 h / 3102.9 Torr
3: 89 percent / pyridine / tetrahydrofuran / 3 h / -15 °C
4: 90 percent / NaOCH3 / tetrahydrofuran / 12 h / Ambient temperature
View Scheme
参考文献
Pirkle, William H.; Simmons, Kirk A.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2520 - 2527
反应条件
1: 90 percent / sodium formate / aq. ethanol / 12 h / Heating
2: 92 percent / NH2OH*HCl, Na2CO3 / aq. ethanol / 24 h / Heating
3: 90 percent / HCl, H2 / 5percent Pd/C / ethanol / 2.5 h / 3102.9 Torr
4: 89 percent / pyridine / tetrahydrofuran / 3 h / -15 °C
5: 90 percent / NaOCH3 / tetrahydrofuran / 12 h / Ambient temperature
View Scheme
参考文献
Pirkle, William H.; Simmons, Kirk A.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2520 - 2527
反应条件
hydrogenchloride in methanol
1) 15 min, 0 deg C; 2) 15 min, room temp.;
参考文献
Miyahara; Nakadate; Kamiya
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 497 - 502
