8-(4-羟基丁基)噻吩并[3,2-c][1]苯并氧杂卓-10(4H)-酮合成路线 （共 4 条）
反应条件
hydrogenchloride in acetone
20 h; Heating;
参考文献
Martin, Lawrence L.; Setescak, Linda L.; Spaulding, Theodore C.; Helsley, Grover C.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 372 - 376
反应条件
1: 82.3 g / K2CO3, KI / butan-2-one / 24 h / Heating
2: aq. KOH / aq. ethanol / 3 h / Heating
3: 84 percent / CH2Cl2 / 4 h / Heating
4: 90 percent / 0.7 M HCl / acetone / 20 h / Heating
View Scheme
参考文献
Martin, Lawrence L.; Setescak, Linda L.; Spaulding, Theodore C.; Helsley, Grover C.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 372 - 376
反应条件
1: 84 percent / CH2Cl2 / 4 h / Heating
2: 90 percent / 0.7 M HCl / acetone / 20 h / Heating
View Scheme
参考文献
Martin, Lawrence L.; Setescak, Linda L.; Spaulding, Theodore C.; Helsley, Grover C.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 372 - 376
反应条件
1: aq. KOH / aq. ethanol / 3 h / Heating
2: 84 percent / CH2Cl2 / 4 h / Heating
3: 90 percent / 0.7 M HCl / acetone / 20 h / Heating
View Scheme
参考文献
Martin, Lawrence L.; Setescak, Linda L.; Spaulding, Theodore C.; Helsley, Grover C.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 372 - 376
