T=37°C; 24 h; synthesis with lipase modified with palmitoyl group; Boc, lauroyl and Z groups used also;

immobilized Candida antarctica Lipase B in neat (no solvent) T=60°C; 1 h; Green chemistryEnzymatic reaction;

immobilized Candida antarctica Lipase B in neat (no solvent) T=60°C; 0.5 h; Green chemistryEnzymatic reaction;

1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C / |Inert atmosphere 2: Dess-Martin periodane / dichloromethane / 1.5 h / |Inert atmosphere 3: methyl (triphenylphosphoranylidene)acetate / tetrahydrofuran / 2.5 h / |Reflux; |Inert atmosphere 4: copper(l) iodide; N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisobutylaluminium hydride / tetrahydrofuran / 4 h / 0 °C / |Inert atmosphere View Scheme

hydrogen in methanol T=20°C; 3 h;

T=65°C; P=0.01 - 0.1 Torr; 72 h; 10percent dosage immobilized nonregiospecific yeast lipase from Candida antarctica;

1: With water; sodium hydroxide in methanol T=20°C; 1.5 h; 2: With hydrogenchloride in water Cooling with ice;

ethylenediaminetetraacetic acid; (ethylenedinitrilo)tetraacetic acid disodium salt in ethanol; water T=60 - 65°C; 2 h;

1: With water; sodium hydroxide in methanol T=20°C; 1.5 h; 2: With hydrogenchloride in water Cooling with ice;

1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C / |Inert atmosphere 2: Dess-Martin periodane / dichloromethane / 1.5 h / |Inert atmosphere 3: methyl (triphenylphosphoranylidene)acetate / tetrahydrofuran / 2.5 h / |Reflux; |Inert atmosphere 4: copper(l) iodide; N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisobutylaluminium hydride / tetrahydrofuran / 4 h / 0 °C / |Inert atmosphere 5: potassium hydroxide / water; methanol / 1 h / 20 - 50 °C / pH 2 / |Inert atmosphere View Scheme