1: With sodium methylate in methanol T=20°C; 116 h; 2: With sulfuric acid in methanol T=60°C; pH=1; 19 h; 3: With sodium carbonate in tert-butyl methyl ether; water T=0°C; pH=9;

sodium methylate in dichloromethane T=20°C; 24 h;

1.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Cooling with water 1.2: 67 h / 20 °C 1.3: 1 h / 5 °C / pH 1.5 2.1: hydrogen / [Ru(OAc)2((S)-2-Furyl-MeOBIPHEP)] / methanol / 20 h / 30 °C / 30003 Torr / Inert atmosphere 3.1: sulfuric acid / 19 h / 60 °C 3.2: 0 °C / pH 9 4.1: sodium methylate / methanol / 116 h / 20 °C 4.2: 19 h / 60 °C / pH 1 4.3: 0 °C / pH 9 View Scheme

1.1: hydrogen / [Ru(OAc)2((S)-2-Furyl-MeOBIPHEP)] / methanol / 20 h / 30 °C / 30003 Torr / Inert atmosphere 2.1: sulfuric acid / 19 h / 60 °C 2.2: 0 °C / pH 9 3.1: sodium methylate / methanol / 116 h / 20 °C 3.2: 19 h / 60 °C / pH 1 3.3: 0 °C / pH 9 View Scheme

1.1: caesium carbonate; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 41 h / 35 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Cooling with water 2.2: 67 h / 20 °C 2.3: 1 h / 5 °C / pH 1.5 3.1: hydrogen / [Ru(OAc)2((S)-2-Furyl-MeOBIPHEP)] / methanol / 20 h / 30 °C / 30003 Torr / Inert atmosphere 4.1: sulfuric acid / 19 h / 60 °C 4.2: 0 °C / pH 9 5.1: sodium methylate / methanol / 116 h / 20 °C 5.2: 19 h / 60 °C / pH 1 5.3: 0 °C / pH 9 View Scheme

1.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Cooling with water 1.2: 67 h / 20 °C 1.3: 1 h / 5 °C / pH 1.5 2.1: hydrogen / [Ru(OAc)2((S)-2-Furyl-MeOBIPHEP)] / methanol / 20 h / 30 °C / 30003 Torr / Inert atmosphere 3.1: sulfuric acid / 19 h / 60 °C 3.2: 0 °C / pH 9 4.1: sodium methylate / methanol / 116 h / 20 °C 4.2: 19 h / 60 °C / pH 1 4.3: 0 °C / pH 9 View Scheme

1.1: sulfuric acid / 19 h / 60 °C 1.2: 0 °C / pH 9 2.1: sodium methylate / methanol / 116 h / 20 °C 2.2: 19 h / 60 °C / pH 1 2.3: 0 °C / pH 9 View Scheme

1: With 1-chloroethyl chlorocarbonate in dichloromethane T=0 - 20°C; 48 h; 2: With 1-chloroethyl chlorocarbonate; triethylamine in dichloromethane T=0 - 20°C; 1.5 h;