5-氯-2,3-二甲氧基苯甲醛合成路线 （共 8 条）
反应条件
1: 5-chloro-2-hydroxy-3-methoxybenzaldehyde With potassium carbonate in N,N-dimethyl-formamide T=22 - 29°C; 0.25 h; 2: dimethyl sulfate in N,N-dimethyl-formamide T=28 - 61°C; 2 h;
参考文献
PREDIX PHARMACEUTICALS HOLDINGS, INC.
Patent: WO2006/81332 A1, 2006 ;
Location in patent: Page/Page column 134-135 ;
WO 2006/081332 A1
反应条件
potassium carbonate in acetone 5 h; Heating;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 458 - 463
Zhurnal Organicheskoi Khimii, , vol. 19, # 3 p. 522 - 528
反应条件
potassium carbonate in acetone 5 h; Heating;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 458 - 463
Zhurnal Organicheskoi Khimii, , vol. 19, # 3 p. 522 - 528
反应条件
1: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h 2: 75 percent / K2CO3 / acetone / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 458 - 463
Zhurnal Organicheskoi Khimii, , vol. 19, # 3 p. 522 - 528
反应条件
1: 45 percent / chlorine / acetic acid / 5 h / 20 °C 2: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h 3: 75 percent / K2CO3 / acetone / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 458 - 463
Zhurnal Organicheskoi Khimii, , vol. 19, # 3 p. 522 - 528
反应条件
in diethyl ether T=20°C; 4 h; Reflux;
参考文献
Laboratorios Del. Dr. Esteve, S.A.
Patent: EP2103596 A1, 2009 ;
Location in patent: Page/Page column 50 ;
反应条件
magnesium 2.) ether, benzene, reflux, 6 h; Yield given. Multistep reaction;
参考文献
Kuleshyus, V. A.; Gaidyalis, P. G.; Pyatrauskas, O. Yu.; Daukshas, V. K.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 7 p. 551 - 553
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 7 p. 827 - 830
反应条件
1: 1.) Mg / 2.) ether, benzene, reflux, 6 h 2: 85 percent / CrO3, pyridine / CH2Cl2 / 0.25 h View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 22, # 7 p. 551 - 553
Khimiko-Farmatsevticheskii Zhurnal, , vol. 22, # 7 p. 827 - 830
