N2-[4-(二乙基氨基)丁基]-6-(3,5-二甲氧基苯基)-吡啶并[2,3-d]嘧啶-2,7-二胺合成路线 （共 5 条）
反应条件
aminosulfonic acid
T=140 - 180°C;
参考文献
GILEAD SCIENCES, INC.; WATKINS, William, J.
Patent: WO2006/47507 A2, 2006 ;
Location in patent: Page/Page column 147-148 ;
WO 2006/047507 A2
反应条件
in 1,4-dioxane
T=50°C;
参考文献
Thompson, Andrew M.; Delaney, Amy M.; Hamby, James M.; Schroeder, Mel C.; Spoon, Teresa A.; Crean, Sheila M.; Showalter, H. D. Hollis; Denny, William A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4628 - 4653
反应条件
1: 18.30 g / 2-(phenylsulfonyl)-3-phenyloxaziridine / CHCl3 / 24 h / 20 °C
2: 72 percent / dioxane / 50 °C
View Scheme
参考文献
Thompson, Andrew M.; Delaney, Amy M.; Hamby, James M.; Schroeder, Mel C.; Spoon, Teresa A.; Crean, Sheila M.; Showalter, H. D. Hollis; Denny, William A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4628 - 4653
反应条件
1.1: NaH / tetrahydrofuran / 1.5 h / 20 °C
1.2: tetrahydrofuran / 20 °C
2.1: 18.30 g / 2-(phenylsulfonyl)-3-phenyloxaziridine / CHCl3 / 24 h / 20 °C
3.1: 72 percent / dioxane / 50 °C
View Scheme
参考文献
Thompson, Andrew M.; Delaney, Amy M.; Hamby, James M.; Schroeder, Mel C.; Spoon, Teresa A.; Crean, Sheila M.; Showalter, H. D. Hollis; Denny, William A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4628 - 4653
反应条件
1.1: NaH / tetrahydrofuran / 1.5 h / 20 °C
1.2: tetrahydrofuran / 20 °C
2.1: 18.30 g / 2-(phenylsulfonyl)-3-phenyloxaziridine / CHCl3 / 24 h / 20 °C
3.1: 72 percent / dioxane / 50 °C
View Scheme
参考文献
Thompson, Andrew M.; Delaney, Amy M.; Hamby, James M.; Schroeder, Mel C.; Spoon, Teresa A.; Crean, Sheila M.; Showalter, H. D. Hollis; Denny, William A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4628 - 4653
