5-[2-(1,1-二甲基乙基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-b]吡啶-2-胺合成路线 （共 2 条）
反应条件
1: {6-[2-tert-butyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-3-nitro-pyridin-2-yl}-(2,2-dimethyl-propyl)-amine With hydrogen; palladium 10 on activated carbon in ethanol
2: bromocyane in ethanol; water
T=20°C;
3: With sodium hydrogencarbonate in ethanol; water
Saturated solution; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/75478 A1, 2005 ;
Location in patent: Page/Page column 49 ;
WO 2005/075478 A1
反应条件
1: With ammonium acetate; acetic acid in methanol
20 h; Heating / reflux;
2: With sodium hydrogencarbonate in water; ethyl acetate
Saturated solution; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/75478 A1, 2005 ;
Location in patent: Page/Page column 55-56 ;
WO 2005/075478 A1
