反应条件
1: NaBH4, cyclopentene / ethanol; tetrahydrofuran / 0.5 h / -40 °C
2: 1) I2,imidazole, Ph3P, 2) aq.H2O2 / 1) benzene-acetonitrile at 23 deg C for 15 min
3: 99 percent / acetonitrile / 40 h / 60 °C
4: 1) potassium hexamethyldisilazide / 1) THF, -20 deg C, 5 min, 2) -78 deg C (30 min) to 23 deg C over 2 h
5: 1N aq.LiOH / 1,2-dimethoxy-ethane / 3 h / 23 °C
View Scheme
参考文献
Corey, E. J.; Nagata, Ryu
Tetrahedron Letters, 1987 , vol. 28, # 45 p. 5391 - 5394
