1: 1.) n-butyllithium, 2.) hexamethylphosphorictriamide / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1 h then at -78 deg C to -20 deg C, 1.5 h 2: 1.) 0.1 percent tosic acid; 2.) aq. lithium hydroxide / 1.) methanol, 23 deg C, 1.5 h; 2.) methanol, THF, 23 deg C, 1.5 h View Scheme