1-(2,2-二氟苯并二氧代-5-基)环丙烷甲腈合成路线 （共 11 条）
反应条件
1: sodium hydroxide; water / ethanol / 80 °C
2: thionyl chloride / toluene / 60 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: hydrogen / 5 palladium on charcoal / tetrahydrofuran / 96 h / 50 °C / 2250.23 - 3000.3 Torr / autoclave; Inert atmosphere
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参考文献
VERTEX PHARMACEUTICALS INCORPORATED; LOOKER, ADAM; Littler, Benjamin Joseph; Choudhury, Anusuya; Harrison, Cristian; Veluri, Ravikanth; Ryan, Michael P.; Jiang, Licong; Luss-Lusis, Eduard
Patent: US2013/116238 A1, 2013 ;
