1-(2,2-二氟-苯并[1,3]二氧代l-5-基)-环丙烷羧酸合成路线 （共 12 条）
反应条件
1: thionyl chloride / toluene / 60 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: hydrogen / 5 palladium on charcoal / tetrahydrofuran / 96 h / 50 °C / 2250.23 - 3000.3 Torr / autoclave; Inert atmosphere
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参考文献
VERTEX PHARMACEUTICALS INCORPORATED; LOOKER, ADAM; Littler, Benjamin Joseph; Choudhury, Anusuya; Harrison, Cristian; Veluri, Ravikanth; Ryan, Michael P.; Jiang, Licong; Luss-Lusis, Eduard
Patent: US2013/116238 A1, 2013 ;
反应条件
1: thionyl chloride / toluene / 2 h / 60 °C
2: 5 palladium on charcoal; hydrogen; hydrogenchloride / methanol / |Inert atmosphere
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参考文献
VERTEX PHARMACEUTICALS INCORPORATED; VAN GOOR, Fredrick, F.
Patent: WO2013/185112 A1, 2013 ;
